Since one century scientists try to find out about the cause of inflammatory bowel diseases. New techniques make it possible to examine whether there exist specific genetic profiles that cause chronic diseases. For Crohn’s disease we know today that genes only make a minor contribution to its development.
The trend in nature science, and that really makes me happy to observe, is to recognize that most of the chronic diseases cannot be explained by one cause only. The same applies to Crohn’s disease (CD). Genetic studies proved this clearly.
I want to raise the topic of CD because biestmilch proved to be a very good therapeutic agent in Crohn’s disease. Of course, I ask myself why this is the case, where is the scientific evidence that gives us a reasonable explanation? Now, a group of scientists from the University of the City London, medicine department presents an interesting concept about the multi-causal roots of CD.
In all CD patients examined scientists found abnormalities that indicate minor defects in a bunch of genes and not a single one. Probably they will discover many more of this kind. We must know that various genes contribute to the creation for example of signal transduction molecules etc. Defects on the level of molecules are called phenotypic, on the level of genes science speaks about ontogenetic defects.
Okay then, various phenotypic failures in CD have been detected recently: a mucosal barrier dysfunction, innate immunodefiency states, and the propagation of a chronic inflammatory state. This vicious circle is perpetuating. (more…)






